Titration to an effective dose is often unattainable3
![](https://www.ztlido.com/wp-content/uploads/2022/11/disclaimer.png)
![](https://www.ztlido.com/wp-content/uploads/2022/11/effacacy.png)
adaptive, randomized, open-label study (N=98) in patients with PHN; chart shows patients treated with pregabalin alone, then in combination with a ZTlido equivalent.1†
Study design1
![](https://www.ztlido.com/wp-content/uploads/2022/11/se1-1-1.png)
Stage 1:
Patients randomized to 4 weeks’ monotherapy with either
- Pregabalin titrated to effect
- All patients received 150 mg/day in week 1 and 300 mg/day in week 2
- At the end of week 2, dose increased to 600 mg/day in
patients with insufficient relief (NRS >4)
- ZTlido: up to 3 patches/day (12 hours on, 12 hours off)
STAGE 2:
- Sufficiently treated with monotherapy (NRS ≤4), continued the same agent for 8 weeks
- Insufficiently treated with monotherapy (NRS >4), received both drugs in combination for 8 weeks
- Results presented from patients insufficiently treated with pregabalin monotherapy
*ZTlido equivalent; "ZTlido equivalent" connotes that study was performed using bioequivalent lidocaine 5% patch.
†Concomitant analgesics not permitted, except rescue acetaminophen (≤2 g/day).
‡11-point NRS (0=no pain to 10=pain as bad as you can imagine).
*SF-MPQ pain intensity was assessed on a VAS of 0 (no pain) to 100 (worst possible pain).
†ZTlido equivalent.
"ZTlido equivalent" connotes that study was performed using bioequivalent lidocaine 5% patch.
IMPORTANT SAFETY INFORMATION
Side effects of ZTlido include application site reactions such as irritation, erythema, and pruritus. These are not all of the adverse reactions that may occur.
TESTIMONIAL
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Hear what your peers are saying about ZTlido
Ensure adequate coverage of the painful area
![](https://www.ztlido.com/wp-content/uploads/2023/03/3_patches.png)
Use daily for at least 8 weeks
![](https://www.ztlido.com/wp-content/uploads/2023/03/PRN_Icon.png)
To get the full therapeutic effect, ZTlido must be used as prescribed every day (not PRN) for at least 8 weeks.
Do not allow substitutions
![](https://www.ztlido.com/wp-content/uploads/2023/03/sticky-note-1.png)
ZTlido is not AB-rated/ interchangeable with other lidocaine patches.11
Provide co-pay card and track progress
![](https://www.ztlido.com/wp-content/uploads/2023/03/brochure.png)
![](https://www.ztlido.com/wp-content/uploads/2024/03/ZTlido_CoPay_Card_2024_XX_sm.png)